Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. Acuta

By Shuangxin Lu, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotaro Murakami, Davaadagva Damdinjav, Enkhjargal Dorjbal, Yoshiki Kashiwada

August 13, 2018

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Title

Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. Acuta

Author

Shuangxin Lu, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotaro Murakami, Davaadagva Damdinjav, Enkhjargal Dorjbal, Yoshiki Kashiwada

Year

2016

Journal

Journal of Natural Medicines

Abstract

Two tetrahydroxanthones, 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1) and 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), and six new tetrahydroxanthone glycosides, amarellins A–F (3–8), were isolated from the aerial parts of a Mongolian medicinal plant Gentianella amarella ssp. acuta (Gentianaceae). The structures of 1–8 were elucidated on the basis of spectroscopic analysis, chemical conversion, and ECD calculation. Amarellins A–C (3–5) were assigned as 8-O-β-d-glucoside, 8-O-β-d-xyloside, and 1-O-β-d-glucoside of 1, respectively, while amarellins D–F (6–8) were elucidated to be 8-O-β-d-xyloside, 1-O-β-d-glucoside, and 3-O-β-d-glucoside of 2, respectively.

Full Article

https://link.springer.com/article/10.1007/s11418-016-1015-z

Instrument

J-1500

Keywords

Circular dichroism, Cotton effect, Stereochemistry, Natural products, Medicinal