Title
New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
Author
Keiko Ogawa, Seikou Nakamura, Kohei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda
Year
2018
Journal
Journal of Natural Medicines
Abstract
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.
Instrument
J-1500
Keywords
Circular dichroism, Absolute configuration, Stereochemistry, Cotton effect, Natural products, Medicinal, Pharmaceutical