Title
Thioquinomycins A-D, novel naphthothiophenediones from the marine-derived Streptomyces sp. SS17F
Author
Dashan Zhang, Yongjun Jiang, Jiaqi Li, Wanjing Ding, Zhe Chen, Zhongjun Ma
Year
2018
Journal
Tetrahedron
Abstract
Thioquinomycins A-D (1–4), four novel naphthothiophenediones were isolated from the rice-based medium of the marine-derived Streptomyces sp. SS17F. Their structures were elucidated by spectroscopic methods and HRESIMS data. The absolute configurations of all the compounds were elucidated by X-ray diffraction analysis, ECD and Mosher's method combined with 19F-NMR. Compounds 1–4showed moderate cytotoxicity against NCI-H1975 with IC50 values from 17.5 to 50 μM. In addition, compounds 1–4 also exhibited inhibitory activities against PKCα and ROCK2 protein kinase.
Instrument
J-1500
Keywords
Circular dichroism, Absolute configuration, Organic chemistry, Medicinal