Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

By Yanchao Xu, Cong Wang, Haishan Liu, Guoliang Zhu, Peng Fu, Liping Wang, Weiming Zhu

October 11, 2018

  • Year

  • Technique

  • Industry

Title

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Author

Yanchao Xu, Cong Wang, Haishan Liu, Guoliang Zhu, Peng Fu, Liping Wang, Weiming Zhu

Year

2018

Journal

Marine Drugs

Abstract

Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1–5, 7, 9 and 10 showed weak α-glucosidase inhibition with the IC50 values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively.

Full Article

https://www.mdpi.com/1660-3397/16/10/363

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Cotton effect, Natural products, Medicinal