52 articles for the search > coronavirus

Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease

2005 / Journal of Biological Chemistry

The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS …

Leah Pandiscia, PhD

Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

2006 / Viral Research

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is the cause of an atypical pneumonia that affected Asia, North America and Europe …

Leah Pandiscia, PhD

Identification and Characterization of the Putative Fusion Peptide of the Severe Acute Respiratory Syndrome-Associated Coronavirus Spike Protein

2005 / Journal of Virology

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a newly identified member of the family Coronaviridae and poses a serious public …

Leah Pandiscia, PhD

Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

2006 / FEBS Letters

The coronavirus nucleocapsid (N) protein binds viral RNA to form the ribonucleocapsid and regulate RNA synthesis. The interaction of N protein with viral RNA was investigated …

Leah Pandiscia, PhD

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease

2007 / Journal of Biological Chemistry

SARS-CoV 3C-like protease (3CLpro) is an attractive target for anti-severe acute respiratory syndrome (SARS) drug discovery, and its dimerization has …

Leah Pandiscia, PhD

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

2020 / Cell Research

The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to …

Leah Pandiscia, PhD

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins

2020 / Cold Spring Harbor Laboratory - Preprint

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate …

Heather Haffner

High-throughput screening of stabilizers for Respiratory Syncytial Virus: Identification of stabilizers and their effects on the conformational thermostability of viral particles

2007 / Human Vaccines

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infection inchildren worldwide. Recombinant live attenuated viral preparations are …

Leah Pandiscia, PhD

Stability of Secondary and Tertiary Structures of Virus-Like Particles Representing Noroviruses: Effects of pH, Ionic Strength, and Temperature and Implications for Adhesion to Surfaces

2015 / Applied and Environmental Microbiology

Loss of ordered molecular structure in proteins is known to increase their adhesion to surfaces. The aim of this work …

Leah Pandiscia, PhD