Coronavirus (CoV) entry is mediated by the viral spike (S) glycoprotein, a class I viral fusion protein. During viral and… Continue reading The Aromatic Domain of the Coronavirus Class I Viral Fusion Protein Induces Membrane Permeabilization:  Putative Role during Viral Entry

The coronavirus infectious bronchitis virus (IBV) nucleocapsid (N) protein is an RNA binding protein which is phosphorylated at two conserved clusters. Kinetic analysis of RNA binding indicated that the C-terminal phosphorylation cluster… Continue reading Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein

The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS… Continue reading Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is the cause of an atypical pneumonia that affected Asia, North America and Europe… Continue reading Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

The helicase from severe acute respiratory syndrome coronavirus (SARS‐CoV) possesses NTPase, duplex RNA/DNA‐unwinding and RNA‐capping activities that are essential for… Continue reading Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a newly identified member of the family Coronaviridae and poses a serious public… Continue reading Identification and Characterization of the Putative Fusion Peptide of the Severe Acute Respiratory Syndrome-Associated Coronavirus Spike Protein

The causative agent of a recent outbreak of an atypical pneumonia, known as severe acute respiratory syndrome (SARS), has been… Continue reading Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus

The coronavirus nucleocapsid (N) protein binds viral RNA to form the ribonucleocapsid and regulate RNA synthesis. The interaction of N protein with viral RNA was investigated… Continue reading Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the… Continue reading The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. It is a type 1 viral fusion protein… Continue reading Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core

SARS-CoV 3C-like protease (3CLpro) is an attractive target for anti-severe acute respiratory syndrome (SARS) drug discovery, and its dimerization has… Continue reading Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease

The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells. It contains two hydrophobic heptad repeat (HR) regions, denoted HRN and… Continue reading Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus