(±)-Neonardochinone A, a pair of enantiomeric neoligans from Nardostachys chinensis with their anti-Alzheimer’s disease activities
Pei-Qian Wu, Bing Li, Yi-Fan Yu, Ye Zhao, Chun-Xue Yu, De-Juan Zhi, Feng-Ming Qi, Pan-Jie Su, Ru-Yue Wang, Dong-Qing Fei, Zhan-Xin Zhang
A pair of new enantiomeric neoligans, (±)-neonardochinone A (1) were isolated from Nardostachys chinensis. The structure of 1 was determined by extensive spectroscopic analysis, containing IR, HRESIMS, NMR spectra and single crystal X-ray diffraction. The enantiomeric separation was finished by HPLC on a chiral column. The absolute configurations were assigned via comparison of their calculated and experimental ECD data. The anti-Alzheimer’s disease (AD) activities of 1, 1a, and 1b were also evaluated using the Caenorhabditis elegans AD pathological model, respectively, and 1 had the highest anti-AD activity.
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical