KnowledgeBase Articles Archive

A novel fluorescent peptidyl probe for highly sensitive and selective ratiometric detection of Cd(II) in aqueous and bio-samples via metal ion-mediated self-assembly

2018 / New Journal of Chemistry

It is still a significant challenge to synthesize ratiometric fluorescent probes based for Cd2+ ions in aqeuous solutions and biosamples.… Continue reading A novel fluorescent peptidyl probe for highly sensitive and selective ratiometric detection of Cd(II) in aqueous and bio-samples via metal ion-mediated self-assembly

Characterization of bovine serum albumin and (-)-epigallocatechin gallate/3,4-O-dicaffeoylquinic acid/tannic acid layer-by-layer assembled microcapsule for protecting immunoglobulin G in stomach digestion and releasing in small intestinal tract

2018 / Journal of Agricultural and Food Chemistry

The protein-polyphenols layer-by-layer (LbL) assembled polymer composite microcapsule is a considerable delivery system that can be used to improve the… Continue reading Characterization of bovine serum albumin and (-)-epigallocatechin gallate/3,4-O-dicaffeoylquinic acid/tannic acid layer-by-layer assembled microcapsule for protecting immunoglobulin G in stomach digestion and releasing in small intestinal tract

Doxorubicin-loaded casein nanoparticles for drug delivery: Preparation, characterization and in vitro evaluation

2018 / International Journal of Biological Macromolecules

Casein, a milk protein that self-assembles to form micelles in aqueous solution, can bind to a wide range of drugs (hydrophilic and… Continue reading Doxorubicin-loaded casein nanoparticles for drug delivery: Preparation, characterization and in vitro evaluation

A highly bioactive Lys-deficient IFN leads to a site-specific di-PEGylated IFN with equivalent bioactivity to that of unmodified IFN-α2b

2018 / ACS Synthetic Biology

Although conjugation with polyethylene glycol (PEGylation) improves the pharmacokinetics of therapeutic proteins, it drastically decreases their bioactivity. Site-specific PEGylation counters… Continue reading A highly bioactive Lys-deficient IFN leads to a site-specific di-PEGylated IFN with equivalent bioactivity to that of unmodified IFN-α2b

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

2018 / Marine Drugs

Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with… Continue reading Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Characterization of the structural changes of human serum albumin upon interaction with single-walled and multi-walled carbon nanotubes: spectroscopic and molecular modeling approaches

2018 / Research on Chemical Intermediates

Through the incorporation of spectorescopic and molecular methods of modeling, the researchers investigated the interaction between Carbon Nanotubes (CNTs) and… Continue reading Characterization of the structural changes of human serum albumin upon interaction with single-walled and multi-walled carbon nanotubes: spectroscopic and molecular modeling approaches

Enhanced Direct Electron Transfer of Fructose Dehydrogenase Rationally Immobilized on 2-Amino Anthracene Diazonium Cation Grafted Single-Walled Carbon Nanotube Based Electrode

2018 / ACS Catalysis

In this paper, an efficient direct electron transfer (DET) reaction was achieved between fructose dehydrogenase (FDH) and a glassy carbon… Continue reading Enhanced Direct Electron Transfer of Fructose Dehydrogenase Rationally Immobilized on 2-Amino Anthracene Diazonium Cation Grafted Single-Walled Carbon Nanotube Based Electrode

Hydrophobic Residue in Escherichia coli Thioredoxin Critical for the Processivity of T7 DNA Polymerase

2018 / Biochemistry

Bacteriophage T7 uses the thioredoxin of its host, Escherichia coli, to enhance the processivity of its DNA polymerase, a requirement for… Continue reading Hydrophobic Residue in Escherichia coli Thioredoxin Critical for the Processivity of T7 DNA Polymerase

Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

2018 / PLoS Pathogens

G-quadruplex (G4), formed by repetitive guanosine-rich sequences, is known to play various key regulatory roles in cells. Herpesviruses containing a… Continue reading Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

Liquid crystal gelators with photo-responsive and AIE properties

2018 / Materials Chemistry Frontiers

A series of new liquid crystal (LC) gelators with photo-responsive and AIE properties were synthesized by connecting cholesterol and tetraphenylethylene… Continue reading Liquid crystal gelators with photo-responsive and AIE properties

Realizing Enhanced Luminescence of Silver Nanoclusters-Peptide Soft Hydrogels by PEI Reinforcement

2018 / Soft Matter

Metal nanoclusters (NCs) are a new type of fluorescent nanomaterials composed of several to several tens of metal ions or… Continue reading Realizing Enhanced Luminescence of Silver Nanoclusters-Peptide Soft Hydrogels by PEI Reinforcement

Syntheses and crystal structures of neodymium(III) and europium(III) complexes bearing dimethyl-, pyrrolidine-, or S-prolinol- dithiocarbamato ligands and their natural and magnetic circular dichroism spectra

2019 / Inorganica Chimica Acta

A series of NdIII and EuIII complexes containing achiral or chiral dithiocarbamato (dtc) ligands, [Ln(Xdtc)3(NN)] {Ln = Nd or Eu; X = dimethyl- (Me2), pyrrolidine- (pyr),… Continue reading Syntheses and crystal structures of neodymium(III) and europium(III) complexes bearing dimethyl-, pyrrolidine-, or S-prolinol- dithiocarbamato ligands and their natural and magnetic circular dichroism spectra

Chiral self-sorted multifunctional supramolecular biocoordination polymers and their applications in sensors

2018 / Nature Communications

Chiral supramolecules have great potential for use in chiral recognition, sensing, and catalysis. Particularly, chiral supramolecular biocoordination polymers (SBCPs) provide… Continue reading Chiral self-sorted multifunctional supramolecular biocoordination polymers and their applications in sensors

Enzymatic hydrolysis of PET: functional roles of three Ca2+ ions bound to a cutinase-like enzyme, Cut190*, and its engineering for improved activity

2018 / Applied Microbiology and Biotechnology

Cut190 from Saccharomonospora viridis AHK190 (Cut190) is the only cutinase that exhibits inactive (Ca2+-free) and active (Ca2+-bound) states, although other homologous cutinases… Continue reading Enzymatic hydrolysis of PET: functional roles of three Ca2+ ions bound to a cutinase-like enzyme, Cut190*, and its engineering for improved activity

Morphological Evaluation of Meta-stable Oligomers of α-Synuclein with Small-Angle Neutron Scattering

2018 / Scientific Reports

Amyloidogenesis of α-synuclein (αS) is considered to be a pathological phenomenon related to Parkinson’s disease (PD). As a key component… Continue reading Morphological Evaluation of Meta-stable Oligomers of α-Synuclein with Small-Angle Neutron Scattering

CPProtectides: Rapid uptake of well‐folded β‐hairpin peptides with enhanced resistance to intracellular degradation

2018 / Peptide Science

Cell penetrating peptides (CPPs) have emerged as powerful tools for delivering bioactive cargoes, such as biosensors or drugs to intact… Continue reading CPProtectides: Rapid uptake of well‐folded β‐hairpin peptides with enhanced resistance to intracellular degradation

Insight into Stereo-Induction by Minor Modification in the Ligand in DNA-Based Hybrid Catalysis

2018 / Catalysis Letters

A pair of bisbenzimidazole derivatives as catalytic ligand was evaluated in DNA-based hybrid asymmetric reaction. Similar structure of both ligands… Continue reading Insight into Stereo-Induction by Minor Modification in the Ligand in DNA-Based Hybrid Catalysis

N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro

2018 / Emerging Microbes & Infections

Human papillomavirus (HPV) is the causative agent in genital warts and nearly all cervical, anogenital, and oropharyngeal cancers. Nine HPV… Continue reading N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro

Direct induction of microtubule branching by microtubule nucleation factor SSNA1

2018 / Nature Cell Biology

Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching… Continue reading Direct induction of microtubule branching by microtubule nucleation factor SSNA1

Structural basis of antiviral activity of peptides from MPER of FIV gp36

2018 / PLoS ONE

Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodeficiency syndrome in felines. It is considered a useful non-primate model… Continue reading Structural basis of antiviral activity of peptides from MPER of FIV gp36

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