Found 9617 Results / Page 211 of 481
2018 / Journal of Cellular Biochemistry
Amyloid fibrillation is associated with several human maladies, such as Alzheimer’s, Parkinson’s, Huntington’s diseases, prions, amyotrophic lateral sclerosis, and type… Continue reading Stabilizing proteins to prevent conformational changes required for amyloid fibril formation
2018 / Phytochemistry Letters
The bark of Morella salicifolia (Hochst.exA. Rich.) Verdc. &Polhill (Myricaceae) is a common herbal drug and especially utilized by the Maasai community of northeastern… Continue reading Dioic acid glycosides, tannins and methylated ellagic acid glycosides from Morella salicifolia bark
2019 / Biochimica et Biophysica Acta (BBA) - General Subjects
HIV-1 matrix protein p17 variants (vp17s) detected in HIV-1-infected patients with non-Hodgkin’s lymphoma (HIV-NHL) display, differently from the wild-type protein… Continue reading Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants
2018 / ACS Catalysis
Thymidylate synthase (TSase), an enzyme responsible for the de novo biosynthesis of 2′-deoxythymidine 5′-monophosphate (thymidylate, dTMP) necessary for DNA synthesis,… Continue reading Experimental and computational studies delineate the role for asparagine 177 in hydride transfer for E. coli thymidylate synthase.
2018 / Marine Drugs
Six new tetracenomycin congeners, saccharothrixones E–I (1–5) and 13-de-O-methyltetracenomycin X (6), were isolated from the rare marine-derived actinomycete Saccharothrix sp. 10-10. Their… Continue reading Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10
2018 / The Journal of Steriod Biochemistry and Molecular Biology
The dominant vector of dengue and Zika diseases is a female Aedes aegypti mosquito. Its reproduction is controlled by the… Continue reading The intrinsically disordered C-terminal F domain of the ecdysteroid receptor from Aedes aegypti exhibits metal ion-binding ability
2018 / small
Amyloidogenic peptides can self‐assemble into highly ordered nanostructures consisting of cross β‐sheet‐rich networks that exhibit unique physicochemical properties and high… Continue reading Thioflavin T‐Amyloid Hybrid Nanostructure for Biocatalytic Photosynthesis
2018 / Scientific Reports
Incorporating membrane proteins into membrane mimicking systems is an essential process for biophysical studies and structure determination. Monodisperse lipid nanodiscs… Continue reading Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc
2019 / Journal of Pharmaceutical and Biomedical Analysis
The ADMET profile of drugs is strongly affected by human serum albumin (HSA), due to its leading role as carrier… Continue reading New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy
2018 / JACS
ABSTRACT: A multi-technique spectroscopic and theoretical study of the Cp2M(benzenedithiolato) (M=Ti,V,Mo; Cp = η5-C5H5) series provides deep insight into dithiolene… Continue reading Vibrational Control of Covalency Effects Related to the Active Sites of Molybdenum Enzymes
2018 / Journal of Natural Products
Sixteen 3,5-dimethylorsellinic acid–based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D–M (1–10), were obtained from Aspergillus terreus. The structures and absolute… Continue reading BACE1 Inhibitory Meroterpenoids from Aspergillus terreus
2018 / Archives of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is… Continue reading Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
2018 / Journal of Natural Products
Four new medermycin-type naphthoquinones, strepoxepinmycins A–D (1–4), and one known compound, medermycin (5), were identified from Streptomyces sp. XMA39. Their structures were… Continue reading Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39
2018 / Nature
The regular arrangements of β-strands around a central axis in β-barrels and of α-helices in coiled coils contrast with the… Continue reading De novo design of a fluorescence-activating β-barrel
2018 / Molecular Biology Reports
Study on the binding properties of helicid by pepsin systematically using multi-spectroscopic techniques and molecular docking method, and these interactions… Continue reading Multi-spectroscopic studies on the interaction between traditional Chinese herb, helicid with pepsin
2018 / Sensors and Actuators B: Chemical
AuNPs-DNA probes remain a challenge to recognize the double-stranded DNA(dsDNA) from routine PCR product despite its success in the recognition of… Continue reading A universal colorimetric PCR biosensor based upon triplex formation with the aid of Ru(phen)2dppx2+
2018 / Chemistry of Natural Compounds
A new dibenzocyclooctadiene lignan, longipedunin E (1), and a new natural product, benzoyl oxokadsuranol (2), together with seven known compounds 3–9,… Continue reading A New Dibenzocyclooctadiene Lignan from Kadsura longipedunculata
2018 / Organic & Biomolecular Chemistry
A common problem encountered in enantioselective organocatalysis is the aggregation of the catalyst, which can result in a relevant decrease… Continue reading Organocatalysis and catalyst aggregation: a study using the asymmetric synthesis of benzofuranones as a test reaction
2018 / PLoS ONE
Heavy metal-associated (HMA) domains bind metal ions at its Cys-x-x-Cys (CxxC) motif and constitute an intracellular network for trafficking of… Continue reading Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metalassociated domain
2018 / Genes
Protein lysine acetylation is a widely conserved posttranslational modification in all three domains of life. Lysine acetylation frequently occurs in… Continue reading Lysine Acetylation Regulates Alanyl-tRNA Synthetase Activity in Escherichia coli
