Found 9617 Results / Page 213 of 481
2018 / Chemistry A European Journal
Spatiotemporal control over the regulation of intra‐ and intermolecular motions in naturally occurring systems is systematically studied to expand the… Continue reading Reversible Photocontrol of DNA Melting by Visible‐Light‐Responsive F4‐Coordinated Azobenzene Compounds
2018 / Metabolic Brain Disease
Single amino acid mutations in profilin 1 (PFN1) have been found to cause amyotrophic lateral sclerosis (ALS). Recently, we developed… Continue reading Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis
2018 / New Journal of Chemistry
Spectrophotometric, spectropolarimetric, viscometric and spectrofluoimetric analysis of the binding of the alkaloid nitidine to the double and triple helical forms… Continue reading Assessment of intercalative interaction of the benzophenanthridine plant alkaloid nitidine with higher ordered forms of RNA: Spectroscopic evaluation
2018 / Biomacromolecules
Incorporating charged amino-acid side chains in polypeptides polymer backbone to improve solubility, usually leads to reduced secondary structuring. Here we… Continue reading IONIC POLYPEPTIDE POLYMERS WITH UNUSUAL β-SHEET STABILITY
2018 / International Journal of Molecular Sciences
The differential transcriptional expression of CLIC4 between tumor cells and the surrounding stroma during cancer progression has been suggested to have a… Continue reading A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression
2018 / PNAS
Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states.… Continue reading Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis
2018 / Bioconjugate Chemistry
Three chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the… Continue reading Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
2018 / Dalton Transactions
The reaction of the antimetastatic ruthenium(III) drug NAMI A with human H-chain ferritin (HuHf) was investigated through a variety of… Continue reading The NAMI A – human ferritin system: a biophysical characterization
2018 / Molecular Genetics and Metabolism
Fabry disease (FD) is an X-linked lysosomal storage disease. It is caused by deficiency of the enzyme α-galactosidase A (α-Gal A), which leads to excessive… Continue reading Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease
2018 / Organic & Biomolecular Chemistry
An organocatalytic enantioselective Mannich reaction between rhodanines and isatin-derived ketimines was developed. With 2 mol% of a quinine-based tertiary amine-thiourea… Continue reading Enantioselective Mannich reaction between rhodanines and isatin-derived ketimines to construct vicinal tetrasubstituted stereocenters
2018 / Macromolecular Rapid Communications
The synthesis of ABA and ABA′ triblock polyethylene glycol‐and polysarcosine‐peptide conjugates is reported. The A/A′ peptides are based on phenylalanine(F)‐histidine(H)… Continue reading Secondary Structure‐Driven Hydrogelation Using Foldable Telechelic Polymer–Peptide Conjugates
2018 / Scientific Reports
In order to study how acidic pro-peptides inhibit the antimicrobial activity of antimicrobial peptides, we introduce a simple model system,… Continue reading An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment
2018 / Journal of Molecular Structure
Herein, we have investigated the effect of cationic gemini surfactant (hexanediyl-α,ω-bis-(N-(2-hydroxyethyl)N-methylhexadecylammonium bromide), (16-6-16MEA) and its monomeric counterpart (N-(2-hyroxyethyl)N, N-dimethylhexadecylammonium bromide), (16MEA) on… Continue reading Comparative effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability of phospholipase A2
2018 / Nucleic Acids Research
Pfh1, the sole member of the Pif1 helicases in Schizosaccharomyces pombe, is multifunctional and essential for maintenance of both the… Continue reading The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity
2018 / Chemistry A European Journal
A homoleptic zinc(II) helicate organized by a pair of achiral dipyrromethene ligands through zinc(II)‐coordination were synthesized to evaluate the chiroptical… Continue reading Significant Enhancement of Absorption and Luminescence Dissymmetry Factors in the Far‐red Region: Zinc(II) Homoleptic Helicate Formed by a Pair of Achiral Dipyrromethene Ligands
2018 / Tetrahedron
Thioquinomycins A-D (1–4), four novel naphthothiophenediones were isolated from the rice-based medium of the marine-derived Streptomyces sp. SS17F. Their structures were elucidated… Continue reading Thioquinomycins A-D, novel naphthothiophenediones from the marine-derived Streptomyces sp. SS17F
2018 / The Journal of Antibiotics
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307.… Continue reading Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
2018 / Molecules
Lactobacillus plantarum is one of the most predominant species in the human gut microbiota of healthy individuals. We have previously characterized… Continue reading Structural Characterization of the Lactobacillus Plantarum FlmC Protein Involved in Biofilm Formation
2018 / Nucleic Acids Research
BZ junctions, which connect B-DNA to Z-DNA, are necessary for local transformation of B-DNA to ZDNA in the genome. However,… Continue reading Sequence preference and structural heterogeneity of BZ junctions
2018 / International Journal of Quantum Chemistry
A theoretical and experimental characterization of N(1)‐(2′,3′‐dihydroxypropil)thymine (DHPT), a potential prebiotic nucleoside analogue of 5‐methyluridine, is performed. A proposed methodology… Continue reading Theoretical and experimental evidence of conformational transformation in stereoisomers of nucleoside analogues
