KnowledgeBase Articles

The ability of peptides to self-assemble represents a valuable tool for the development of biomaterials of biotechnological and/or biomedical interest.… Continue reading Assembly modes of hexaphenylalanine variants as function of the charge states of their terminal ends.

Four new glyco-conjugated tacrine derivatives, 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (1), 4-(2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (2), 2′-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1′,3′-thiazolidin-4′-one (3) and [2′-(1,2,3,4-tetrahydro-acridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4′-oxothiazolidin-5-yliden]acetate (4) were synthesized and their characteristics were… Continue reading Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y

Prothymosin-α is a small, multifunctional intrinsically disordered protein associated with cell survival and proliferation which binds multiple Zn2+ ions and undergoes… Continue reading Zn2+‑binding in the glutamate‑rich region of the intrinsically disordered protein prothymosin‑alpha

The rice hoja blanca virus (RHBV), transmitted by the planthopper insect Tagosodes orizicolus, is a disease that attacks rice and generates… Continue reading Conformationally Restricted Peptides from Rice Proteins Elicit Antibodies That Recognize the Corresponding Native Protein in ELISA Assays

In recent years, air pollution has been a subject of great scientific and public interests for the strong impact on… Continue reading The porcine odorant-binding protein as molecular probe for benzene detection

Rapid and accurate determination of H2O2 is of great importance in practical applications. In this study, we demonstrate construction of… Continue reading Fabrication of liquid crystal-based optical sensing platform for detection of hydrogen peroxide and blood glucose

The 2′‐O,4′‐C‐methylene‐bridged nucleic acid (2′,4′‐BNA/LNA), having an N‐type sugar conformation, effectively improves duplex‐forming ability. 2′,4′‐BNA/LNA is widely used to improve… Continue reading 2′‐O,4′‐C‐Methylene‐bridged nucleic acids stabilize metal‐mediated base pairing in a DNA duplex

Two pairs of chiral cyano-bridged heterobimetallic compounds, [Mn(salen)Ru((R,R)-(5-Br-salcy))(CN)2]n (1), [Mn(salen)Ru((S,S)-(5-Br-salcy))(CN)2]n (2), [Ni(tren)][Ru((R,R)-(5-Cl-salcy))(CN)2]2 (3), and [Ni(tren)][Ru((S,S)-(5-Cl-salcy))(CN)2]2 (4) [salcy2− = N,N’-(1,2-cyclohexanediylethylene) bis(salicylideneiminato)… Continue reading Synthesis, structures and magnetic properties of heterbimetallic RuIII-3d (3d = Mn, Ni) compounds based on the chiral RuIII building block

Which conformational parameters lead to an antibody-affine peptide antigen? And in how many different conformations can we actually present the… Continue reading A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes

Several findings propose the altered tau protein network as an important target for Alzheimer’s disease (AD). Particularly, two points of… Continue reading Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

The data presented in this article are related to the research article entitled “Immunomodulatory and Enhanced Antitumor Activity of a… Continue reading Effects on tumor growth and immunosuppression of a modified Tα1 peptide along with its circular dichroism spectroscopy data

Amyloids adopt ‘cross-β’ structures composed of long, twisted fibrils with β-strands running perpendicular to the fibril axis. Recently, a toxic… Continue reading Designed peptides that assemble into cross-α amyloid-like structures

Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a… Continue reading Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements

Carboligations catalyzed by aldolases or thiamine diphosphate (ThDP)-dependent enzymes are well-known in biocatalysis to deliver enantioselective chain elongation reactions. A… Continue reading Extended substrate range of thiamine diphosphate-dependent MenD enzyme by coupling of two C–C-bonding reactions

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play a central role in neuronal and neuromuscular signal transduction.… Continue reading α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor

Despite the importance of membrane proteins in cellular processes, studies of these hydrophobic proteins present major technical challenges, including expression… Continue reading Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions

Protein materials are rapidly gaining interest in materials sciences and nanomedicine because of their intrinsic biocompatibility and full biodegradability. The… Continue reading Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles

Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were… Continue reading Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14

Structural change of lysozyme in the aqueous mixture of ethanol (ETH) has been investigated using emission, circular dichroism spectroscopy, free-energy… Continue reading Spectroscopic and Molecular Dynamics Simulation Study of Lysozyme in the Aqueous Mixture of Ethanol: Insights into the Nonmonotonic Change of the Structure of Lysozyme

Three new indolocarbazoles alkaloids together with nine known compounds were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. A65. Their structures… Continue reading Cytotoxic indolocarbazoles alkaloids from the streptomycessp. A65