Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Developing adhesives that can function underwater remains a major challenge for bioengineering; yet, many marine creatures, exemplified as mussels and… Continue reading Self-Assembled Nanofibers for Strong Underwater Adhesion: the Trick of Barnacles
Leah Pandiscia, PhD
August 13, 2018
Light, oxygen, voltage (LOV) proteins, a ubiquitously distributed class of photoreceptors, regulate a wide variety of light-dependent physiological responses. Due… Continue reading Mechanistic basis of the fast dark recovery of the short LOV protein DsLOV from Dinoroseobacter shibae
Leah Pandiscia, PhD
August 13, 2018
Guanine-rich nucleic acid sequences can fold into four-stranded G-quadruplex (G4) structures. Despite growing evidence for their biological significance, considerable work… Continue reading More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Chiral nanostructures have been attracting extensive interest in recent years primarily because of the unique materials properties that can be… Continue reading Plasmonic circular dichroism of vesicle-like nanostructures by template-less self-assembly of achiral Janus nanoparticles
Leah Pandiscia, PhD
August 13, 2018
We report a new signal readout mechanism for DNA molecular sensing devices using ligand-free fluorogenic G-quadruplexes of which the propeller-like… Continue reading Probing Propeller-Like Loops of DNA G-quadruplexes with Looped-Out 2-Aminopurine for Label-Free Switchable Molecular Sensing
Leah Pandiscia, PhD
August 13, 2018
Seven new pimarane-type diterpene derivatives, libertellenones O–S (1–5) and eutypellenones A and B (6 and 7), together with two known compounds (8 and 9),… Continue reading Libertellenones O–S and Eutypellenones A and B, Pimarane Diterpene Derivatives from the Arctic Fungus Eutypella sp. D-1
Leah Pandiscia, PhD
August 13, 2018
Films capable of broadband circular polarization of light are important for many optical applications. Owing to their intrinsic chiral nematic… Continue reading Broadband Circular Polarizing Film Based on Chiral Nematic Liquid Crystals
Leah Pandiscia, PhD
August 13, 2018
Free-standing, high aspect ratio sulfur-doped carbon nanodots-based hybrid nanowires with a microtubular aspect were synthesized using self-recognition and self-assembly processes… Continue reading Biological self-assembly and recognition used to synthesize and surface guide next generation of hybrid materials
Leah Pandiscia, PhD
August 13, 2018
Rhodamine group of molecules are widely used dyes for imaging of biological molecules. Application of these dyes however includes a… Continue reading Two Photon Spectroscopy Can Serve as a Marker of Protein Denaturation Pathway
Leah Pandiscia, PhD
August 13, 2018
The GC skew in vertebrate mitochondrial genomes results in synthesis of RNAs that are prone to form G-quadruplexes (G4s). Such… Continue reading Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
Leah Pandiscia, PhD
August 13, 2018
The enzyme carboxypeptidase G2 (CPG2) is utilized in antibody directed enzyme pro‐drug therapy (ADEPT) to catalyze the formation of an… Continue reading Characterisation of the Carboxypeptidase G2 Catalytic Site and Design of New Inhibitors for Cancer Therapy
Leah Pandiscia, PhD
August 13, 2018
The G3TG3TG3TG3 (G3T) sequence folds into a monomolecular quadruplex with all-parallel G3 segments connected to each other by chain-reversal loops. The homopolymer… Continue reading Monomolecular tetrahelix of polyguanine with a strictly defined folding pattern
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Microtubule plus end-binding protein, EB1 is a key regulator of microtubule dynamics. Auto-inhibitory interaction in EB1 has previously been shown… Continue reading GTP-binding facilitates EB1 recruitment onto microtubules by relieving its auto-inhibition
Leah Pandiscia, PhD
August 13, 2018
Five new compounds, 9,3′-dimethoxyhierochin A (1), 6-oxo-trans-neocnidilide (2), (±)-(3E)-trans-6-hydroxy-7-methoxydihydroligustilide (3), (±)-cnidiumin (4), and 6-(1-oxopentyl)-salicylic acid methyl ester (5), together with… Continue reading Anti-inflammatory activity of compounds from the rhizome of Cnidium officinale
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018