Leah Pandiscia, PhD
April 9, 2019
In order to improve the previously observed antichagasic activity of Cu(II) complexes containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis… Continue reading In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Stromal interaction molecule (STIM)-1 and -2 regulate agonist-induced and basal cytosolic calcium (Ca2+) levels after oligomerization and translocation to endoplasmic… Continue reading The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains
Leah Pandiscia, PhD
April 9, 2019
Computational design with supersecondary structures as building blocks has proven effective in the construction of new proteins with controlled geometries.… Continue reading Asymmetric protein design from conserved supersecondary structures
Leah Pandiscia, PhD
April 9, 2019
Arginine-Glycine-Aspartate (RGD) tripeptide can promote cell adhesion when present in the amino acid of proteins such as fibronectin. In order… Continue reading An RGD-Containing Peptide Derived from Wild Silkworm Silk Fibroin Promotes Cell Adhesion and Spreading
Leah Pandiscia, PhD
April 9, 2019
Mode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular… Continue reading Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative
Leah Pandiscia, PhD
April 9, 2019
Chemoenzymatic polypeptide synthesis offers several advantages over chemical or other biological routes, however, the use of aqueous-based media suffers from… Continue reading Chemoenzymatic synthesis of polypeptides in neat 1,1,1,2-tetrafluoroethane solvent
Leah Pandiscia, PhD
April 9, 2019
Increasing efforts have been made to assess the potential of Escherichia coli strains for the production of complex recombinant proteins.… Continue reading High level in vivo mucin-type glycosylation in Escherichia coli
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Web spiders synthesize silk fibers of unique strength and extensibility through the controlled self-assembly of protein building blocks, so-called spidroins.… Continue reading Two-step self-assembly of a spider silk molecular clamp
Leah Pandiscia, PhD
April 9, 2019
Phospholipases A2 represent a family of enzymes with important application in medicine. However, direct tracking is difficult due to the absence… Continue reading In vitro tracking of phospholipase A2 from snake venom conjugated with magic-sized quantum dots
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde… Continue reading The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis
Leah Pandiscia, PhD
April 9, 2019
Root exudates from Lotus japonicus were found to contain at least three different hyphal branching-inducing compounds for the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, one of which… Continue reading Lotuslactone, a non-canonical strigolactone from Lotus japonicus
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 8, 2019
In plants and bacteria that use a Type II fatty acid synthase (FAS), isozymes of acyl-acyl carrier protein (ACP) thioesterase… Continue reading Identification of Active Site Residues Implies a Two-step Catalytic Mechanism for Acyl-ACP Thioesterase
Leah Pandiscia, PhD
April 8, 2019
Surgical site infections (SSI) represent a serious health problem that occur after invasive surgery, thus new antimicrobial biomaterials able to… Continue reading Silk‐Based Antimicrobial Polymers as a New Platform to Design Drug‐Free Materials to Impede Microbial Infections
Leah Pandiscia, PhD
April 8, 2019
The human mitochondrial outer membrane protein VDAC2 (voltage-dependent anion channel) is a β-barrel metabolite flux channel that is indispensable for… Continue reading Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2
Leah Pandiscia, PhD
April 8, 2019