A series of new chromone based-Cu(II) complexes 1–3 derived from bioactive pharmacophore, 3-formylchromone and N,N-donor ligands viz., 1,10-phenanthroline, 2,2′-bipyridine and 1R,2R-DACH were synthesized as… Continue reading Design, synthesis and characterization of novel chromone based-copper(II) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity
Leah Pandiscia, PhD
April 8, 2019
Peanut allergy is one of the most common food allergies worldwide. Studies have shown that the incidence of peanut allergies… Continue reading Different thermal processing effects on peanut allergenicity
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
We designed glutamide-derived amphiphilic Schiff bases containing three different aldehyde moieties for the fabrication of circularly polarized luminescence (CPL) emitting… Continue reading Self-Assembly of Amphiphilic Schiff Base and Selectively Turn on Circularly Polarized Luminescence by Al3+
Leah Pandiscia, PhD
April 8, 2019
Spirocurvulaide (1), a novel bicyclic polyketide with an unprecedented spiro[furan-2,2′-naphthalene] ring system, was produced by the fungus Curvularia sp. IFB-Z10 in a… Continue reading Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10
Leah Pandiscia, PhD
April 8, 2019
Pb2+ exposure leads to diverse neurological disorders; however, the mechanism of Pb2+-induced neurotoxicity is not clearly understood. Here we demonstrate that… Continue reading Pb2+ Binds to DREAM and Modulates Its Interactions with Binding Partners: a Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.
Leah Pandiscia, PhD
April 8, 2019
Heather Haffner
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Alternately N-alkylated aromatic amides such as 1 to 3 bearing various side chains were designed and synthesized as novel helical… Continue reading Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers
Leah Pandiscia, PhD
April 8, 2019
Five new limonoids named thaigranatins A–E (1–5), containing a C1–O–C29 moiety, were isolated from seeds of the Thai Xylocarpus granatum, collected at… Continue reading Limonoids Containing a C1–O–C29 Moiety: Isolation, Structural Modification, and Antiviral Activity
Leah Pandiscia, PhD
April 8, 2019
The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and… Continue reading Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis
Leah Pandiscia, PhD
April 8, 2019
As an integral membrane protein, purification and characterization of phospho-N- acetylmuramyl- pentapeptide translocase MraY have proven difficult. Low yield and… Continue reading Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers
Heather Haffner
April 8, 2019
Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7.… Continue reading New Metabolites from Endophytic Fungus Chaetomium globosum CDW7
Leah Pandiscia, PhD
April 8, 2019
Herein, we describe a bright-red-emitting ovalbumin-protected gold nanoclusters (OVA–AuNCs) that were prepared and applied as a luminescent probe for a… Continue reading Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes
Leah Pandiscia, PhD
April 8, 2019
Peptide amphiphile micelles (PAMs) are a nanoparticle platform that have gained popularity for their targeting versatility in a wide range… Continue reading Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes
Leah Pandiscia, PhD
April 8, 2019
Selenium (Se) is a natural trace element, which shifts its action in a relatively narrow concentration range from nutritional role… Continue reading Effects of selenate and red Se-nanoparticles on the photosynthetic apparatus of Nicotiana tabacum
Leah Pandiscia, PhD
April 8, 2019
The aggregation of proteins have been associated with several aspects of daily life, including food processing, blood coagulation and many… Continue reading Inhibition of amyloid fibril formation of β-lactoglobulin by the natural and synthetic curcuminoids
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Because cadmium might interact with proteins and, thus, exert toxicity in organisms, it is vital to understand the molecular mechanism… Continue reading A study on the interaction between cadmium and α‐chymotrypsin and the underlying mechanisms
Leah Pandiscia, PhD
April 8, 2019