Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Pseudoaldosteronism is a common adverse effect associated with traditional Japanese Kampo medicines. The pathogenesis is mainly caused by 3-monoglucuronyl glycyrrhetinic… Continue reading Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism
Leah Pandiscia, PhD
April 8, 2019
The exploitation of SUMO (small ubiquitin-related modifier) fusion technology at a large scale for the production of therapeutic proteins with an authentic N-terminus is… Continue reading Bioprocess optimization for the overproduction of catalytic domain of ubiquitin-like protease 1 (Ulp1) from S. cerevisiaein E. coli fed-batch culture
Leah Pandiscia, PhD
April 8, 2019
Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus… Continue reading Alkaloids and styryllactones from Goniothalamus cheliensis
Leah Pandiscia, PhD
April 8, 2019
Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we… Continue reading A computationally designed peptide derived from Escherichia colias a potential drug template for antibacterial and antibiofilm therapies
Leah Pandiscia, PhD
April 8, 2019
We have previously reported a novel method for measuring the spectral properties and orientation of fluorescent probes in solution, which… Continue reading Fluorescence detected linear dichroism of small molecules oriented on polyethylene film
Leah Pandiscia, PhD
April 8, 2019
Among the insulin‐family peptides, two additional cysteine residues other than six conserved cysteines are sometimes found in invertebrate insulin‐like peptides… Continue reading Chemical synthesis of the crustacean insulin‐like peptide with four disulfide bonds
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Microbial extracellular electron transport occurs via the physical and electrical association of outer-membrane c-type cytochromes (OM c-Cyts) with extracellular solid… Continue reading Geometrical Changes in the Hemes of Bacterial Surface c-type Cytochromes Reveal Flexibility in their Binding Affinity with Minerals
Leah Pandiscia, PhD
April 8, 2019
Manipulating the chiroptical at the nanoscale is of great importance in stereoselective reactions, enantioseparation, self assembly and biological phenoma. In… Continue reading Chirality Inversion on the Carbon Dot Surface via Covalent Surface Conjugation of Cyclic α-Amino Acid Capping Agents
Leah Pandiscia, PhD
April 8, 2019
Heather Haffner
April 8, 2019
Eight novel Tl(I) β-oxodithioester complexes, [TlL]n (1–8) with ligands, L = methyl-3-hydroxy-3-(2-furyl)-2-propenedithioate (L1), methyl-3-hydroxy-3-(2-thienyl)-2-propenedithioate (L2), methyl-3-hydroxy-3-(3-pyridyl)-2-propenedithioate (L3), methyl-3-hydroxy-3-(4-pyridyl)-2-propenedithioate (L4), methyl-3-hydroxy-3-(9-anthracenyl)-2-propenedithioate… Continue reading Cooperative Metal–Ligand Influence on the Formation of Coordination Polymers, Conducting and Photophysical Properties of Tl(I) β-oxodithioester Complexes
Leah Pandiscia, PhD
April 8, 2019
Flash nanoprecipitation (FNP) by fast mixing of drug‐containing organic solvent and water in a microchamber is a powerful and scalable… Continue reading Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation
Leah Pandiscia, PhD
April 8, 2019
Thrombolytic agents are routinely used to dissolve blood clot by activating fibrinolytic system. Among different thrombolytic agents available, staphylokinase (SAK) is gaining… Continue reading Lipid modification of staphylokinase and its implications on stability and activity
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Leah Pandiscia, PhD
April 8, 2019
Baefrutones A–F (1–6), six new meroterpenoids with rare triketone-phloroglucinol-monoterpene/sesquiterpene frameworks, together with their biosynthetically related intermediate (±)-baeckenon B (7), were… Continue reading Atropisomeric meroterpenoids with rare triketone-phloroglucinol-terpene hybrids from Baeckea frutescens
Leah Pandiscia, PhD
April 8, 2019
Protein therapeutics are prone to lose their structure and bioactivity under various environmental stressors. This study reports a facile approach… Continue reading Metal‐Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics
Leah Pandiscia, PhD
April 8, 2019
Aggregation of intrinsically disordered proteins into fibrils is implicated in many neurodegenerative diseases. Amyloid aggregation is a generic property of… Continue reading Amyloid aggregation of Bacillus circulans xylanase under a native condition and its modulation by beta‐amyloid‐derived peptide fragments
Leah Pandiscia, PhD
April 8, 2019