For the first time, the photoisomerization of a diarylethene moiety (DAET) in peptideconjugates was used to probe the effects of molecular… Continue reading Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers
Leah Pandiscia, PhD
March 1, 2019
Low expression and instability are significant challenges in the recombinant production of therapeutic peptides. The current study introduces a novel… Continue reading Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin
Leah Pandiscia, PhD
April 8, 2019
Carbohydrate binding modules (CBMs) are non-catalytic domains within larger multidomain polypeptides. The CelH from Ruminoclostridium (Clostridium) thermocellum contains a family 11 CBM (RtCBM11) with high binding… Continue reading Engineering the affinity of a family 11 carbohydrate binding module to improve binding of branched over unbranched polysaccharides
Leah Pandiscia, PhD
March 1, 2019
Chloroquine (CQ) has been used for decades as the primary chemotherapeutic drugfor the treatment of malaria. The emergence of drug resistance in Plasmodiumfalciparum has been considered to… Continue reading In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance
Leah Pandiscia, PhD
March 1, 2019
Leah Pandiscia, PhD
March 1, 2019
A (diethylamino)coumarin-modified β-cyclodextrin (1) increased its fluorescence intensity upon guest binding in an aqueous media, and this phenomenon was used… Continue reading Highly selective binding behavior of (diethylamino)coumarin-modified β-cyclodextrin with bile acids
Leah Pandiscia, PhD
February 28, 2019
Peroxidases are well-known biocatalysts produced by all organisms, especially microorganisms, and used in a number of biotechnological applications. The enzyme… Continue reading Characterization and use of a bacterial lignin peroxidase with an improved manganese-oxidative activity
Leah Pandiscia, PhD
February 28, 2019
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study… Continue reading 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA
Leah Pandiscia, PhD
February 28, 2019
Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and Alzheimer’s… Continue reading Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme
Leah Pandiscia, PhD
February 28, 2019
Heather Haffner
February 28, 2019
Self-assembly is one of the important and fruitful method to develop various biomaterials especially hydrogels from biologically important small molecules.… Continue reading Biocytin based pH-stimuli responsive supramolecular multivariant hydrogelator for potential applications
Leah Pandiscia, PhD
February 28, 2019
Heather Haffner
February 28, 2019
Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan.… Continue reading Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
Leah Pandiscia, PhD
February 28, 2019
Leah Pandiscia, PhD
February 28, 2019
Leah Pandiscia, PhD
February 28, 2019
Polyhistidine triad proteins, which participate in Zn2+ uptake in Streptococcus pneumoniae, contain multiple copies of the HxxHxH (histidine triad motif)… Continue reading Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+binding?
Leah Pandiscia, PhD
February 28, 2019
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the… Continue reading Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142
Leah Pandiscia, PhD
February 28, 2019
DJ Tognarelli
April 8, 2019
Detailed analysis of biopharmaceuticals is crucial for safety, efficacy and stability. Aptamers, which are folded, single-stranded oligonucleotides, can be used… Continue reading Aptamers as quality control tool for production, storage and biosimilarity of the anti-CD20 biopharmaceutical rituximab
Leah Pandiscia, PhD
April 8, 2019
Marine debris is widely recognized as a global environmental problem. One of its main components, microplastics, has been found in… Continue reading Microplastics in Spanish Table Salt
Carlos Morillo
April 11, 2019