Title
Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities
Author
Na Gao, Zhi-Chun Shang, Pei Yu, Jie Luo, Kai-Li Jian, Ling-Yi Kong, Ming-Hua Yang
Year
2017
Journal
Chinese Chemical Letters
Abstract
One new indoloditerpene, 6,7-dehydropaxilline (1), one new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3), as well as 8 known alkaloids (4–11), were isolated from the soild cultures of the endophytic fungus, Penicillium brefeldianum. The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism (CD) exciton chirality method. All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines. Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC50 values of 14.1 μmol/L and 35.5 μmol/L, respectively. Compound 3 showed moderate activity against HepG2 cells with IC50 values of 36.6 μmol/L.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal