Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides

June 29, 2020

Title

Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides

Author

Yang Liu, Jing Li, Dan Li, Xiao-Min Li, Dai Li, Gan Zhou, Kang-Ping Xu, Feng-Hua Kang, Zhen-Xing Zou, Ping-Sheng Xu, Gui-Shan Tan

Year

2019

Journal

Fitoterpia

Abstract

Phytochemical investigation of the ethyl acetate extract of Lycopodiastrum casuarinoides (Spring) Holub (Lycopodiaceae) led to the isolation of nine compounds, including two new serratene triterpenoids, serrat-14-en-3α,21α-diol (1), 26-nor-8-oxo-21-one-α-onocerin (6), one new abietane diterpenoid, lycocasuarinone A (7), one new sesquiterpene acid, 7, 9-diene-1,4-epoxy-2-hydroxy-10-carboxylic acid (8) and one new chromone derivative, 5,7-dihydroxy-2-methyl esterchromone (9), together with four known serratene triterpenoids (2–5). Abietane diterpenoid (7) and sesquiterpene acid (8) from Lycopodiastrum casuarinoides are reported for the first time. Their structures and stereochemistry were unambiguously elucidated by spectroscopic analysis and comparison with known ones. All the compounds were tested for acetylcholinesterase (AChE) and butyrocholinesterase (BuChE) inhibitory activities. Bioactivity assays revealed that compound 6 exhibited the most potent AChE inhibitory effect.

Instrument

J-815

Keywords

Circular dichroism, Stereochemistry, Agriculture and environmental, Pharmaceutical