Title
Aristolochic acid derivatives from the rhizome of Arisolochia championii
Author
Xin Wang, Guo-Ru Shi, Yan-Fei Liu, Li Li, Ruo-Yun Chen, De-Quan Yu
Year
2017
Journal
Fitoterapia
Abstract
Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5–14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC50 values of 0.50, 7.37, 2.66, and 0.75 μM, respectively.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal