Binuclear Schiff base copper(II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties
Shengshi Jiang, Honghui Ni, Fen Liu, Shanshan Gu, Ping Yu, Yi Gou
Inorganica Chimica Acta
Three binuclear Schiff base copper(II) complexes: [Cu2(HL1)2(CH3OH)(NO3)]·NO3 (1), [Cu2(HL2)2(CH3OH)2]·2NO3 (2), and [Cu2(HL3)2(C2H5OH)2]·2NO3 (3) [HL1 = (E)-N′-(5-fluoro-2-hydroxybenzylidene)benzohydrazide, HL2 = (E)-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide, and HL3 = (E)-N′-(5-bromo-2-hydroxybenzylidene)benzohydrazide], were synthesized and characterized employing various spectroscopic techniques. X-ray crystallography analysis revealed complexes 1–3 to have similar molecular structures. Results from the MTT assay revealed that all copper complexes displayed greater cytotoxicity toward several tumor cell types than cisplatin or the Schiff-base ligands. Further investigations revealed that complex 1 can induce mitochondrion-mediated apoptotic cell death. In addition, the interaction between these Cu(II) complexes and human serum albumin (HSA) was also investigated.
Circular dichroism, Secondary structure, Ligand binding, Inorganic chemistry, Biochemistry, Medicinal