Title
Camouflaged Nanosilver with Excitation Wavelength Dependent High Quantum Yield for Targeted Theranostic
Author
Agnishwar Girigoswami, Wafic Yassine, Palani Sharmiladevi, Viswanathan Haribabu, Koyeli Girigoswami
Year
2018
Journal
Scientific Reports
Abstract
The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumour bearing mice. The initial increment of quantum yield was wavelength dependent and finally it became 0.509 which was due to the camouflaging or entrapment of AgNC in macrophages membranes. The potentiality of macrophages membrane camouflaged silver nanoclusters (AgM) was reflected in the cell viability assay and confocal based live dead cell assay where the AgM has better cell killing effect compared to AgNC with reduced dosage and in vivo mice imaging generated the clear visualization at the tumour sites. Therefore, from the present study, it can be considered that the camouflaged nanosilver can be used for targeted theranostic applications.
Full Article
Instrument
FP-8500
Keywords
Fluorescence, Kinetics, Quantum yield, Chemical stability, Nanostructures, Materials