Cassane diterpenes from the seed kernels of Caesalpinia sappan
Hai Xuan Nguyen, Nhan Trung Nguyen, Phu Hoang Dang, Phuoc Thi Ho, Mai Thanh Thi Nguyen, Mao Van Can, Dya Fita Dibwe, Jun-ya Ueda, Suresh Awale
Eight structurally diverse cassane diterpenes named tomocins A–H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
Circular dichroism, Absolute configuration, Toxicology, Medicinal