Title
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
Author
Taichi Ohshiro, Reiko Seki, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda
Year
2018
Journal
The Journal of Antibiotics
Abstract
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR. Celludinone A was found to be a mixture of racemic isomers ((±)-1), which were isolated by a chiral column. Compounds (+)-1 and (−)-1 inhibited the sterol O-acyltransferase (SOAT) 1 and 2 isozymes in a cell-based assay using SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells, while 2 selectively inhibited the SOAT2 isozyme.
Full Article
Instrument
J-720
Keywords
Circular dichroism, Absolute configuration, Stereochemistry, Cotton effect, Pharmaceutical, Natural products