Coumarin and spirocyclopentenone derivatives from the leaves and stems of Murraya paniculata (L.) Jack
Haizhen Liang, Nankai Cao, Kewu Zeng, Mingbo Zhao, Pengfei Tu, Yong Jiang
Seven previously undescribed compounds, including five coumarins, (+/−)-murpanitin A and murpanitins B-D, and a pair of spirocyclopentenone enantiomers, (+/−)-murrayaspiroketone, along with 14 known coumarin derivatives were isolated from the leaves and stems of Murraya paniculata (L.) Jack. Their structures were elucidated on the basis of comprehensive analysis of 1D and 2D NMR and HRMS spectroscopic data, and the absolute configurations were assigned via calculated and experimental ECD data. Three compounds showed moderate inhibitory effects on nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values of 53.2 ± 8.9, 57.7 ± 5.8, and 53.2 ± 4.4 μM, respectively.
Circular dichroism, Absolute configuration, Stereochemistry, Natural products, Pharmaceutical