Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability

July 28, 2017

Title

Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability

Author

Tanaya Bose, Vaijayanti A. Kumar

Year

2017

Journal

Tetrahedron

Abstract

An uncharged PNA 15mer sequence formed unimolecular antiparallel G-quadruplex similar to that observed for DNA-TBA. Replacement of ‘tt’ loop regions by peptides which induce helices or turns were found to have unpresidented effect on the quadruplex topology and stability. This study opens up a completely new strategy of utilizing G-quadruplex formation to display the array of functional groups in the three dimensional space thus creating a possibility of getting closer to the dream of designed peptides with three dimensional structures as observed in catalytic protein folds.

Instrument

J-815

Keywords

Circular dichroism, DNA structure, Chemical stability, Biochemistry