Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family 

July 28, 2017

Title

Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family 

Author

Teresa Stemeseder, Regina Freier, Sabrina Wildner, Julian E. Fuchs, Peter Briza, Roland Lang, Eva Batanero, Jonas Lidholm, Klaus R. Liedl, Paloma Campo, Thomas Hawranek, Mayte Villalba, Hans Brandstetter, Fatima Ferreira, Gabriele Gadermaier

Year

2016

Journal

Journal of Allergy and Clinical Immunology

Abstract

Solving the structure of Pla l 1 elucidated the preserved fold of Ole e 1-like proteins while IgE cross- 33 reactivity in this family is limited to molecules with high sequence identity. Diagnostic accuracy using 34 source-specific Ole e 1-like molecules is essential for discriminating plantain from other pollen 35 allergies.

Instrument

J-815

Keywords

Circular dichroism, Secondary structure, Thermal stability, Biochemistry