Cytotoxic and Antibacterial Cervinomycins B1–4 from a Streptomyces Species

November 13, 2019

Title

Cytotoxic and Antibacterial Cervinomycins B1–4 from a Streptomyces Species

Author

Xiaowen Hu, Xinxin Hu, Xiaomin Hu, Shufen Li, LinLi Li, Liyan Yu, Hongyu Liu, Xuefu You, Zhen Wang, Li Li, Beibei Yang, Bingya Jiang, Linzhuan Wu

Year

2019

Journal

Journal of Natural Products

Abstract

AntiSMASH analysis of genome DNA of Streptomyces CPCC 204980, a soil isolate with potent antibacterial activity, revealed a gene cluster for polycyclic xanthones. A subsequent chemical study confirmed that the microorganism produced polycyclic xanthone cervinomycin A2 (1) and the new congeners cervinomycins B1–4 (2–5). The structures of 1–5 were determined by comprehensive analyses of MS and NMR data, which indicated that 2–5 featured a common dihydro-D ring in the polycyclic xanthone core moiety of their molecules. 2–5 are toxic to human cancer cells and active against Gram-positive bacteria.

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal