Title
Cytotoxic and Antibacterial Cervinomycins B1–4 from a Streptomyces Species
Author
Xiaowen Hu, Xinxin Hu, Xiaomin Hu, Shufen Li, LinLi Li, Liyan Yu, Hongyu Liu, Xuefu You, Zhen Wang, Li Li, Beibei Yang, Bingya Jiang, Linzhuan Wu
Year
2019
Journal
Journal of Natural Products
Abstract
AntiSMASH analysis of genome DNA of Streptomyces CPCC 204980, a soil isolate with potent antibacterial activity, revealed a gene cluster for polycyclic xanthones. A subsequent chemical study confirmed that the microorganism produced polycyclic xanthone cervinomycin A2 (1) and the new congeners cervinomycins B1–4 (2–5). The structures of 1–5 were determined by comprehensive analyses of MS and NMR data, which indicated that 2–5 featured a common dihydro-D ring in the polycyclic xanthone core moiety of their molecules. 2–5 are toxic to human cancer cells and active against Gram-positive bacteria.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal