Title
Cytotoxic polycyclic polyprenylated acylphloroglucinol derivatives and xanthones from Hypericum attenuatum
Author
Zhong-Bo Zhou, Yang-Mei Zhanga, Jian-Guang Luoa, Ling-Yi Kong
Year
2016
Journal
Phytochemistry Letters
Abstract
Two new polycyclic polyprenylated acylphloroglucinols, attenuatumione G (1) and attenuatumione H (2), together with five known compounds (3–7) have been isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic data including HRESIMS, 1D- and 2D-NMR. In biological assays, compound 2 showed moderate cytotoxic activities against Hep-G2 (IC50 9.11 μM) and MCF-7 (IC50 16.24 μM), compound 4 exhibited significant cytotoxic activity with IC50value of 5.32 μM against Hep-G2, and both compounds 5 and 6 revealed significant nitric oxide production inhibitory activity with IC50 values of 5.52 and 8.46 μM, respectively.
Instrument
J-810
Keywords
Circular dichroism, Agricultural and environmental