Dimeric chromanone, cyclohexenone and benzamide derivatives from the endophytic fungus Xylaria sp. PSU-H182
Athip Maha, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Wimarak Poonsuwan, Jariya Sakayaroj
Five new compounds including three dimeric chromanones (1–3), one cyclohexenone (4) and one benzamide (5), together with four known metabolites, were isolated from the endophytic fungus Xylaria sp. PSU-H182. Their structures were determined by analysis of their spectroscopic data, and the absolute configuration of the chiral axes for 1–3 was determined by circular dichroism spectroscopy. Some of the isolated compounds were evaluated for antimalarial, antimycobacterial and cytotoxic activities.
Circular dichroism, Absolute configuration, Medicinal