Title
DNA groove‐binding ability of luminescent platinum(II) complexes based on a family of tridentate N^N^C ligands bearing differently substituted alkyl tethers
Author
Marian Hebenbrock, Darío González-Abradelo, Cristian A. Strassert, Jens Müller
Year
2018
Journal
Journal of Inorganic and General Chemistry
Abstract
A family of luminescent Pt(II) complexes is presented capable of binding DNA duplexes via groove binding. The complexes are based on a tridentate ligand with N^N^C donor functionality bearing a triazole, a pyridine and a phenyl entity. The triazole group is used to attach a series of pendant dodecane tethers with differently charged functional head groups (neutral hydroxyl group, anionic sulfate group, cationic tetraalkylammonium group). The DNA‐binding behavior of the three resulting Pt(II) complexes was characterized by UV/Vis, CD and luminescence spectroscopy as well as viscosity measurements and computational docking studies. The data clearly indicate groove binding interactions for all three complexes. In addition, a light‐switch effect was observed for the complexes upon the addition of DNA.
Instrument
FP-6500
Keywords
Fluorescence, DNA structure, Inorganic chemistry, DNA binding, Biochemistry