Title
Enantioselective Self-Assembled Nanofibrillar Network with Glutamide-Based Organogelator
Author
Nao Nagamoto
Year
2021
Journal
nanomaterials
Abstract
A chiral molecular gelation system, as a chiral host, was used to effectively realize enantioselectivity using the simple carboxylic acid functional group. For this purpose, an L-glutamic-acid-based lipidic amphiphile (G-CA) with a carboxylic head group was selected and its responsiveness to cationic guest molecules was investigated. The dispersion morphology of G-CA in its solution state was examined by confocal and transmission electron microscopies, while interactions between the G-CA, as the host system, and guest molecules were evaluated by UV-visible, circular dichroism, and fluorescence spectroscopies. As a result, enantioselectivity was effectively induced when G-CA formed highly ordered aggregates that provide negatively charged surfaces in which carboxyl groups are assembled in highly ordered states, and when the two cationic groups of the guest molecule are attached to this surface through multiple interactions.
Full Article
Instrument
V-560, FP-6500, J-725
Keywords
molecular gel; nanofibril; self-assembly; secondary chirality; enantioselectivity; circular dichroism