Evaluation of the chemical quality of Sekkoku in current Japanese commercial crude drugs: constituents of Flickingeria xantholeuca (Rchb. f.) A.D. Hawkes
Mei Muto, Haruka Asahina, Tatsufumi Yoshioka, Kazuo Ozaki, Makio Shibano
Journal of Natural Medicines
In our investigation, most Shihu (石斛; Japanese name, Sekkoku) in current Japanese commercial crude drugs were from Flickingeria xantholeuca (Orchidaceae). As the index compounds, three new ent-pimarane-type diterpenes, flickinxthanthosides A–C (1–3), one known analogue (7), and three new ent-kaurane-type diterpenes, flickinxanthosides D (4) and E (5) and flickinxanthol A (6) were isolated from the stem of F. xantholeuca. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and chemical methods. We attempted to detect these index compounds from the MeOH extracts of other Dendrobiumor Flickingeria plants using TLC and LC/MS.
Circular dichroism, Absolute configuration, Pharmaceutical