Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols fromHypericum sampsonii

July 28, 2017

Title

Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols fromHypericum sampsonii

Author

Wen-Jing Tian, Yu-Qin Qiu, Xiao-Jie Jin, Hai-Feng Chen, Xiao-Jun Yao, Yi Dai, Xin-Sheng Yao

Year

2016

Journal

RSC Advances

Abstract

Five new polycyclic polyprenylated acylphloroglucinols (1–5) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues (6–10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1–5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Medicinal