Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols fromHypericum sampsonii
Wen-Jing Tian, Yu-Qin Qiu, Xiao-Jie Jin, Hai-Feng Chen, Xiao-Jun Yao, Yi Dai, Xin-Sheng Yao
Five new polycyclic polyprenylated acylphloroglucinols (1–5) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues (6–10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1–5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
Circular dichroism, Absolute configuration, Medicinal