Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

February 28, 2019

Title

Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

Author

Yalin Hu, Li Heng, Rong Xu, Junhe Li, Shanshan Wei, Deran Xu, Jun Luo, Yi Li

Year

2018

Journal

molecules

Abstract

Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Cotton effect, Pharmaceutical, Natural products