New α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434
Zhengbo Chen, Jiejie Hao, Liping Wang, Yi Wang, Fandong Kong, Weiming Zhu
Wailupemycins H (1) and I (2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a –CH2– linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds 1 and 2 are two new α-glucosidase inhibitors with the Ki/IC50 values of 16.8/19.7 and 6.0/8.3 μM, respectively. In addition, the absolute configurations of wailupemycins D (3) and E (4) are also resolved in this paper for the first time.
Circular dichroism, Absolute configuration