New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

By Keiko Ogawa, Seikou Nakamura, Kohei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda

August 13, 2018

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Title

New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

Author

Keiko Ogawa, Seikou Nakamura, Kohei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda

Year

2018

Journal

Journal of Natural Medicines

Abstract

Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.

Full Article

https://link.springer.com/article/10.1007/s11418-017-1166-6

Instrument

J-1500

Keywords

Circular dichroism, Absolute configuration, Stereochemistry, Cotton effect, Natural products, Medicinal, Pharmaceutical