Title
New Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
Author
Tao Zhang, Jin-Guang Si, Qiu-Bo Zhang, Gang Ding, Zhong-Mei Zou
Year
2016
Journal
Scientific Reports
Abstract
Eight highly oxygenated germacranolides (1–8) including four new ones (2–5) were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by NMR experiment and HRESIMS data. The absolute configuration of 1 was established by circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds2–5 were determined by similar CD spectra with 1. Compound 2 is the first hydroperoxyl germacrane from the genus Carpesium. The 13C NMR data of 1, NMR data of 6–7, and their absolute configurations were reported for the first time. Two new compounds (2 and 4) and two known compounds (6 and 8) exhibited potent cytotoxicity against human cervical cancer (HeLa) cells, superior to that of the positive control doxorubicin.
Full Article
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Medicinal