Title
New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia
Author
Van-Tuan Vu
Year
2021
Journal
Fitoterapia
Abstract
Four new lignans, patulinones A−D (1–4) and three new acetophenone derivatives, patulinones E−G (5–7) were isolated from the leaves of Melicope patulinervia. Their structures were elucidated on the basis of the interpretation of HR-ESIMS, NMR, CD data. All the isolated compounds were evaluated for α-glucosidase inhibitory activity. Of the isolates, compound 4 was found to exhibit the strongest inhibition against α-glucosidase with IC50 value of 6.02 ± 0.46 μM.
Instrument
P-1020, J-810
Keywords
Lignans, Natural medicine