New neolignans from the seeds of Myristica fragransand their cytotoxic activities

By Parinuch Chumkaew, Theera Srisawat

October 11, 2018

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Title

New neolignans from the seeds of Myristica fragransand their cytotoxic activities

Author

Parinuch Chumkaew, Theera Srisawat

Year

2018

Journal

Journal of Natural Medicines

Abstract

Three new dihydrobenzofuran neolignans, myticaganal A–C (1–3), along with five known compounds (4–8), were isolated from the seeds of Myristica fragrans. Their structures were elucidated by extensive spectroscopic analysis. In vitro cytotoxic activities of the isolated compounds against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer) were evaluated. Neolignan 3 showed significant cytotoxicity against KB and NCI-H187 cell lines with IC50 values of 5.9 and 6.3 μM, respectively.

Full Article

https://link.springer.com/article/10.1007/s11418-018-1246-2

Instrument

J-715

Keywords

Circular dichroism, Absolute configuration, Cotton effect, Natural products, Medicinal