Title
New phenalenone derivatives from Pinellia ternata tubers derived Aspergillus sp.
Author
Surenmandakh Gombodorj, Ming-Hua Yang, Zhi-Chun Shang, Rui-Huan Liu, Tian-Xiao Li, Guo-Ping Yin, Ling-Yi Kong
Year
2017
Journal
Fitoterapia
Abstract
Nine new phenalenone derivatives (1–9), along with two known analogues (10 − 11) have been isolated from the solid cultures of an endophytic fungus Aspergillus sp. which was obtained from Pinellia ternate. Their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ECD) and Mo2(OCOCH3)4 induced ECD. All of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely oxidized and partly epoxidized to form different heterocycles. In addition, compound 10 exhibited significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis with MIC50 values of 1.87, 2.77, and 4.80 μg/mL, respectively.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal