New Spiral γ-Lactone Enantiomers from the Plant Endophytic FungusPestalotiopsis foedan
Xiao-Long Yang, Zhuang-Zhuang Li
(−)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1bshowed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines.
Circular dichroism, Absolute configuration, Pharmaceutical