Title
One new sesquiterpene pyridine alkaloid from the stems and leaves of Euonymus fortunei
Author
Guang-Kai Kuang, Lin Wang, Li-Li Yang, Yu-Bo Zhang, Ding Luo, Yi-Duo Zhou, Neng-Hua Chen, Zhong-Nan Wu, Guo-Cai Wang & Yao-Lan Li
Year
2020
Journal
Journal of Asian Natural Products Research
Abstract
A new sesquiterpene pyridine alkaloid (1), along with four known compounds (2-5), were isolated from the stems and leaves of Euonymus fortunei. The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound 3 showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC50 value of 1.20 ± 0.10 µM than the positive control ribavirin with an IC50 value of 5.62 ± 0.49 µM.