Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

2017 / Food & Function

Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic …

Leah Pandiscia, PhD

Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations

2017 / The Journal of Physical Chemistry B

Biological membranes are heterogeneous structures with complex electrostatic profiles arising from lipids, sterols, membrane proteins, and water molecules. We investigated …

Leah Pandiscia, PhD

Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

2017 / ChemBioChem

Four group A streptococcal glyco-lipopeptide vaccine candidates were prepared and characterized, each possessing different lipidic adjuvanting moieties. The immunogenicity of …

Leah Pandiscia, PhD

Effect of β-Cyclodextrin on the Multistate Species Distribution of 3-Methoxy-4′,7-dihydroxyflavylium. Discrimination of the Two Hemiketal Enantiomers

2017 / Journal of Agricultural and Food Chemistry

The effect of β-cyclodextrin on the mole fraction distribution of the multistate species of the anthocyanin model compound, 3-methoxy-4′,7-dihydroxyflavylium, was …

Leah Pandiscia, PhD

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

2017 / Molecular Neurobiology

Alpha-synuclein (ASN) is a presynaptic protein that can easily change its conformation under different types of stress. It’s assumed that …

Leah Pandiscia, PhD

The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

The formulation glatiramer acetate (GA) is widely used in therapy of multiple sclerosis. GA consists of random copolymers of four …

Leah Pandiscia, PhD

Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens

2017 / Journal of Photochemistry and Photobiology B: Biology

In the present study, we focused on a quick and green method to fabricate Ag, Au and Ag/Au alloy nanoparticles …

Leah Pandiscia, PhD

Development of a subunit vaccine for prevention of Clostridium difficile associated diseases: biophysical characterization of toxoids A and B

2017 / Biochemistry and Biophysics Reports

Inactivation of bacterial toxins for use in human vaccines traditionally is achieved by treatment with formaldehyde. In contrast, the bivalent …

Leah Pandiscia, PhD

UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties

2017 / International Journal of Biological Macromolecules

Peptidoglycan (PG) is the key component of the bacterial cell wall. The enzyme UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) catalyzes the transfer …

Leah Pandiscia, PhD

Interaction of octahedral ruthenium(II) polypyridyl complex [Ru(bpy)2(PIP)]2 + with poly(U)•poly(A)*poly(U) triplex:increasing third-strand stabilization of the triplex without affecting the stability of the duplex

2017 / Journal of Inorganic Biochemistry

Triple-helical RNA are of interest because of possible biological roles as well as the potential therapeutic uses of these structures, …

Leah Pandiscia, PhD