Basigin interacts with Plasmodium vivax tryptophan-rich antigen PvTRAg38 as a second erythrocyte receptor to promote parasite growth

2016 / The Journal of Biological Chemistry

Elucidating molecular mechanisms of host-parasite interaction during red cell invasion by Plasmodium is important to develop newer antimalarial therapeutics. Recently, …

Leah Pandiscia, PhD

Dual function of Ixr1 in transcriptional regulation and recognition of cisplatin-DNA adducts is caused by differential binding through its two HMG-boxes

2016 / Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Ixr1 is a transcriptional factor involved in the response to hypoxia, which is also related to DNA repair. It binds …

Leah Pandiscia, PhD

Inhibitory effects of the dietary flavonoid quercetin on the enzyme activity of zinc(II)-dependent yeast alcohol dehydrogenase: Spectroscopic and molecular docking studies

2017 / International Journal of Biological Macromolecules

A multispectroscopic exploration was employed to investigate the interaction between the metallo-enzyme alcohol dehydrogenase (ADH) from yeast with bioflavonoid quercetin …

Leah Pandiscia, PhD

Heterogeneous Cationic Liposomes Modified with 3β-{N-[(N′,N′-Dimethylamino)ethyl]carbamoyl}cholesterol Can Induce Partial Conformational Changes in Messenger RNA and Regulate Translation in an Escherichia coli Cell-Free Translation System

2013 / Langmuir

The effect of cationic liposomes (CLs) on messenger RNA(mRNA) conformation and translation was studied, focusing on membrane heterogeneity. CLs, composed …

Leah Pandiscia, PhD

Temperature-Triggered Switchable Helix-Helix Inversion of Poly(phenylacetylene) Bearing l-Valine Ethyl Ester Pendants and Its Chiral Recognition Ability

2016 / Molecules

A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh4) to produce the …

Leah Pandiscia, PhD

Binding properties of the natural red dye carthamin with human serum albumin: Surface plasmon resonance, isothermal titration microcalorimetry, and molecular docking analysis

2016 / Food Chemistry

The interaction between carthamin and human serum albumin (HSA) was investigated by multiple spectroscopic analyses, surface plasmon resonance (SPR), isothermal …

Leah Pandiscia, PhD

Targeted delivery system for cancer cells consist of multiple ligands conjugated genetically modified CCMV capsid on doxorubicin GNPs complex

2016 / Scientific Reports

Targeted nano-delivery vehicles were developed from genetically modified Cowpea chlorotic mottle virus (CCMV) capsid by ligands bioconjugation for efficient drug delivery in …

Leah Pandiscia, PhD

Testing the dependence of stabilizing effect of osmolytes on the fractional increase in the accessible surface area on thermal and chemical denaturations of proteins

2016 / Archives of Biochemistry and Biophysics

Here we have generated two different denatured states using heat- and guanidinium chloride (GdmCl) – induced denaturations of three disulfide …

Leah Pandiscia, PhD