Conjugation of cytochrome c with ferrocene-terminated hyperbranched polymer and its influence on protein structure, conformation and function

2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Interaction mechanism of a new hyperbranched polyurethane-based ferrocene (HPU-Fc) with cytochrome c (cyt c) and cyt c structure and conformation change induced by HPU-Fc were …

Leah Pandiscia, PhD

Spectroscopic investigations on partial intercalative binding behaviour of terpyridine based copper(II) complexes with DNA

2016 / Journal of Photochemistry and Photobiology B: Biology

Copper based metal complexes have been studied extensively towards DNA interaction aspects, the possible interactions being at the major or …

Leah Pandiscia, PhD

Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational Stability

2016 / PLoS ONE

Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we …

Leah Pandiscia, PhD

Murine erythroid 5-aminolevulinate synthase: Truncation of a disordered N-terminal extension is not detrimental for catalysis

2016 / Biochimica et Biophysica Acta-Proteins and Proteomics

5-Aminolevulinate synthase (ALAS), a pyridoxal 5′-phosphate (PLP)-dependent homodimeric enzyme, catalyzes the initial step of heme biosynthesis in non-plant eukaryotes. The …

Leah Pandiscia, PhD

Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide–membrane interactions of three related antimicrobial peptides

2016 / Colloids and Surfaces B: Biointerfaces

Cationic antimicrobial peptides (CAMPs) represent important self defense molecules in many organisms, including humans. These peptides have a broad spectrum …

Leah Pandiscia, PhD

Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near‐ and far‐UV CD for protein higher order structural analysis

2011 / Journal of Pharmaceutical Sciences

Circular dichroism (CD) spectroscopy is routinely used in the biopharmaceutical industry to study the effects of manufacturing, formulation, and storage …

Leah Pandiscia, PhD