Circular Dichroism and Magnetic Circular Dichroism Studies of the Active Site of p53R2 from Human and Mouse: Iron Binding and Nature of the Biferrous Site Relative to Other Ribonucleotide Reductases

2006 / Biochemistry

Ribonucleotide reductases (RNR) catalyze the rate-limiting step in the synthesis of deoxyribonucleotides from the corresponding ribonucleotides in the synthesis of …

Leah Pandiscia, PhD

Spontaneous Deposition of Porphyrin-Based Layers on Polylysinated Substrates: Role of the Central Metal on Layer Structural and Sensing Properties

2016 / Journal Physical Chemistry C

Noncovalent porphyrin deposition onto polylysinated surfaces proceeds by obeying the self-assembly rules experienced in aqueous solution. In particular, the porphyrin’s …

Leah Pandiscia, PhD

Molecular Aspects of the Interaction of Iminium and Alkanolamine Forms of the Anticancer Alkaloid Chelerythrine with Plasma Protein Bovine Serum Albumin

2016 / Journal Physical Chemistry B

The interaction between a quaternary benzophenanthridine alkaloid chelerythrine (herein after, CHL) and bovine serum albumin (herein after, BSA) was probed …

Leah Pandiscia, PhD

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein−Protein Interaction in the Shelterin Complex

2016 / Journal of Medicinal Chemistry

Shelterin, a six-protein complex, plays a fundamental role in protecting both the length and the stability of telomeres. Repressor activator …

Leah Pandiscia, PhD

New Red-Emitting Conjugated Polyelectrolyte: Stabilization by Interaction with Biomolecules and Potential Use as Drug Carriers and Bioimaging Probes

2016 / ACS Applied Materials and Interfaces

The design and development of fluorescent conjugated polyelectrolytes (CPEs) emitting in the red region of the visible spectrum is at …

Leah Pandiscia, PhD

The Pathogenic Mutation T182A Converts the Prion Protein into a Molten Globule-like Conformation Whose Misfolding to Oligomers but Not to Fibrils Is Drastically Accelerated

2016 / Biochemistry

Delineation of the effects of pathogenic mutations linked with familial prion diseases on the structure and misfolding of prion protein …

Leah Pandiscia, PhD

Detection and Resolution of Intermediate Species in Protein Folding Processes Using Fluorescence and Circular Dichroism Spectroscopies and Multivariate Curve Resolution

2002 / Analytical Chemistry

Thermally induced protein unfolding/folding processes have been studied on α-lactalbumin and α-apolactalbumin. Experiments monitored by fluorescence and circular dichroism spectroscopic …

Leah Pandiscia, PhD