Interaction of p-benzoquinone with hemoglobin in smoker’s blood causes alteration of structure and loss of oxygen binding capacity

2016 / Toxicology Reports

Cigarette smoke (CS) is an important source of morbidity and early mortality worldwide. Besides causing various life-threatening diseases, CS is …

Leah Pandiscia, PhD

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds

2016 / International Journal of Biological Macromolecules

Three new diphenylsubstituted spirotriazolidine- and thiazolidinone–acridines were prepared and their interaction with calf thymus DNA investigated with UV–vis, fluorescence, circular …

Leah Pandiscia, PhD

A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function

2016 / Nature Communications

Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. …

Leah Pandiscia, PhD

Emulsification-Induced Homohelicity in Racemic Helical Polymer for Preparing Optically Active Helical Polymer Nanoparticles

2016 / Macromolecular Rapid Communications

Optically active nano- and microparticles have constituted a significant category of advanced functional materials. However, constructing optically active particles derived …

Leah Pandiscia, PhD

Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques

2016 / Scientific Reports

Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors implicated in secondary complications of diabetes. …

Leah Pandiscia, PhD

Tempo-spatial chirogenesis. Limonene-induced mirror symmetry breaking of Sisingle bondSi bond polymers during aggregation in chiral fluidic media

2016 / Journal of Photochemistry and Photobiology A: Chemistry

Herein, we designed photoluminescent polymer aggregates surrounded by organic media containing (S)-/(R)-limonene and (1S)-/(1R)-α-pinene as an artificial model of an …

Leah Pandiscia, PhD

Urea-induced denaturation of human calcium/calmodulin-dependent protein kinase IV: a combined spectroscopic and MD simulation studies

2016 / Journal of Biomolecular Structure and Dynamics

Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is a multifunctional enzyme which belongs to the Ser/Thr kinase family. CaMKIV plays important role …

Leah Pandiscia, PhD

Colorimetric Strategy for Highly Sensitive and Selective Simultaneous Detection of Histidine and Cysteine Based on G-Quadruplex-Cu(II) Metalloenzyme

2016 / Analytical Chemistry

In this present work, we proposed a colorimetric strategy for simultaneous detection of histidine and cysteine based on G-quadruplex-Cu(II) metalloenzyme …

Leah Pandiscia, PhD

Acceleration of bone formation during fracture healing by poly(pro–hyp–gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

2016 / Journal of Biomedical Materials Research Part A

Growth factor delivered in combination with animal-derived collagen materials has been used to accelerate bone fracture healing in human patients. …

Leah Pandiscia, PhD