Analytical techniques and bioactivity assays to compare the structure and function of filgrastim (granulocyte-colony stimulating factor) therapeutics from different manufacturers

2014 / Analytical and Bioanalytical Chemistry

The FDA has approved more than 100 protein and peptide drugs with hundreds more in the pipeline (Lanthier et al. …

Leah Pandiscia, PhD

Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene

2014 / PROTEOMICS - Clinical Applications

In this study, we investigated whether the phenotypic difference observed between two lattice corneal dystrophy type 1 (LCD type 1) …

Leah Pandiscia, PhD

Four new compounds from Ligularia virgaurea: isolation of eremophilane and noreremophilane sesquiterpenoids and the absolute configuration of 2α-hydroxyeremophil-11-en-9-one by CD spectrum and DFT calculation

2013 / Tetrahedron

Four new compounds, rearranged noreremophilan-8,6-olide, rearranged dinoreremophilanone, epoxy γ-lactone, and 2α-hydroxyermophil-11-en-9-one, along with eremophilenolides related to ligularol and other known …

Leah Pandiscia, PhD

5-Hydroxymethyl-2′-Deoxyuridine Residues in the Thrombin Binding Aptamer: Investigating Anticoagulant Activity by Making a Tiny Chemical Modification

2014 / ChemBioChem

We report an investigation into analogues of the thrombin binding aptamer (TBA). Individual thymidines were replaced by the unusual residue …

Leah Pandiscia, PhD

Agarose functionalization: Synthesis of PEG-agarose amino acid nano-conjugate – its structural ramifications and interactions with BSA in a varying pH regime

2016 / Carbohydrate Polymers

In a rapid one-step method protein-mimicking large agarose amino acid framework (AAE; GPC 156.7 kDa) was conjugated with polyethylene glycol (PEG …

Leah Pandiscia, PhD

Colloidal chirality in wormlike micellar systems exclusively originated from achiral species: Role of secondary assembly and stimulus responsivity

2016 / Journal of Colloid and Interface Science

Colloidal chirality in wormlike micellar systems exclusively originated from achiral species and discussion of the role of secondary assembly of …

Leah Pandiscia, PhD