High-level expression and efficient refolding of therapeutically important recombinant human Interleukin-3 (hIL-3) in E. coli

2017 / Protein Expression and Purification

Human interleukin-3 (hIL-3) is a pleiotropic cytokine that stimulates the differentiation and proliferation of multipotent hematopoietic cells thus making it …

Leah Pandiscia, PhD

Structural and functional studies of the Leishmania braziliensismitochondrial Hsp70: Similarities and dissimilarities to human orthologues

2017 / Archives of Biochemistry and Biophysics

Heat shock protein 70 kDa (Hsp70) is a conserved molecular chaperone family involved in several functions related to protein homeostasis. In …

Leah Pandiscia, PhD

Two Zinc(II) metal-organic frameworks with mixed ligands of 5-amino-tetrazolate and l,2,4,5-benzenetetracarboxylate: synthesis, structural diversity and photoluminescent properties ☆

2016 / Journal of Solid State Chemistry

The reactions of Zn(NO3)2∙6H2O with mixed ligands of 5-amino-tetrazole (Hatz) and l,2,4,5-benzenetetracarboxylic acid (H4btec) under hydro(solvo)thermal conditions, gave two three-dimensional …

Leah Pandiscia, PhD

Isoniazid inhibits human erythroid 5-aminolevulinate synthase: Molecular mechanism and tolerance study with four X-linked protoporphyria patients

2016 / Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Mutations in the C-terminus of human erythroid 5-aminolevulinate synthase (hALAS2), a pyridoxal 5′-phosphate (PLP)-dependent enzyme, are associated with two different …

Leah Pandiscia, PhD

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

2016 / Biochimica et Biophysica Acta (BBA) - General Subjects

Guanine-rich DNA motifs can form non-canonical structures known as G-quadruplexes, whose role in tumorigenic processes makes them attractive drug-target candidates …

Leah Pandiscia, PhD

Recurring sequence-structure motifs in (βα)8-barrel proteins and experimental optimization of a chimeric protein designed based on such motifs

2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

An interesting way of generating novel artificial proteins is to combine sequence motifs from natural proteins, mimicking the evolutionary path …

Leah Pandiscia, PhD

Investigation on interaction of DNA and several cationic surfactants with different head groups by spectroscopy, gel electrophoresis and viscosity technologies

2016 / Chemosphere

In this study, the interaction between DNA and several cationic surfactants with different head groups such as ethyl hexadecyl dimethyl …

Leah Pandiscia, PhD

Dibenzo-α-pyrones: a new class of larvicidal metabolites against Aedes aegypti from the endophytic fungus Hyalodendriella sp. Ponipodef12

2016 / Pest Management Science

In our course to find new agrochemicals from endophytic fungi, the crude extract of the endophytic Hyalodendriella sp. Ponipodef12 associated with the …

Leah Pandiscia, PhD

Enantiopure C1-symmetric N-Heterocyclic Carbene Ligands from Desymmetrized meso-1,2-Diphenylethylenediamine: Application in Ruthenium-Catalyzed Olefin Metathesis

2016 / Catalysts

In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis, enantiomeric catalysts incorporating C1-symmetric N-Heterocyclic carbenes (NHC) ligands with syn-related substituents …

Leah Pandiscia, PhD