Copper Complexes Based on Chiral Schiff-base Ligands: DNA/BSA Binding Ability, DNA Cleavage Activity, Cytotoxicity and Mechanism of Apoptosis

2016 / European Journal of Medicinal Chemistry

Four copper(II) complexes with chiral Schiff-base ligands, [Cu(R-L1)2]·EtOAc (1) and [Cu(S-L1)2]·EtOAc (2), [Cu(R-L2)2]·EtOAc (3) and [Cu(S-L2)2]·EtOAc (4), (R/S-HL1 = (R/S)-(1-naththyl)-salicylaldimine, R/S-HL2 = (R/S)-(1-naththyl)-3-methoxysalicylaldimine, EtOAc = ethyl acetate) …

Leah Pandiscia, PhD

Proteolytically-induced changes of secondary structural protein conformation of bovine serum albumin monitored by Fourier transform infrared (FT-IR) and UV-circular dichroism spectroscopy

2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Enzymatically-induced degradation of bovine serum albumin (BSA) by serine proteases (trypsin and α-chymotrypsin) in various concentrations was monitored by means …

Leah Pandiscia, PhD

Interaction of an anti-cancer photosensitizer with a genomic DNA: From base pair specificity and thermodynamic landscape to tuning the rate of detergent-sequestered dissociation

2016 / Journal of Colloid and Interface Science

A detailed characterization of the binding interaction of a potent cancer cell photosensitizer, norharmane (NHM) with a genomic DNA (herring …

Leah Pandiscia, PhD

Selective disruption of disulphide bonds lowered activation energy and improved catalytic efficiency in TALipB fromTrichosporon asahii MSR54: MD simulations revealed flexible lid and extended substrate binding area in the mutant

2016 / Biochemical and Biophysical Research Communications

TALipB (33 kDa) is a solvent stable, enantioselective lipase from Trichosporon asahiiMSR54. It is cysteine-rich and shows activation in presence of thiol …

Leah Pandiscia, PhD

Isolation, characterization and molecular three-dimensional structural predictions of metalloprotease from a phytopathogenic fungus, Alternaria solani (Ell. and Mart.) Sor.

2016 / Journal of Bioscience and Bioengineering

The present study aims at isolation, identification, characterization and prediction of three-dimensional molecular architecture of a proteolytic enzyme from the …

Leah Pandiscia, PhD

The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition

2016 / Journal of Structural Biology

Chemotaxis and motility play an important role in the colonisation of avian and human hosts by Campylobacter jejuni. Chemotactic recognition of …

Leah Pandiscia, PhD

Physicochemical properties and antioxidant activities of two fucosylated chondroitin sulfate from sea cucumber Acaudina molpadioidea and Holothuria nobilis

2016 / Process Biochemistry

The physicochemical properties and antioxidant activities of two fucosylated chondroitin sulfate (ACP and HOP) isolated from sea cucumber Acaudina molpadioidea andHolothuria nobilis respectively …

Leah Pandiscia, PhD

Investigation on the protein-binding properties of icotinib by spectroscopic and molecular modeling method

2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Icotinib is a highly-selective epidermal growth factor receptor tyrosine kinase inhibitor with preclinical and clinical activity in non-small cell lung …

Leah Pandiscia, PhD