Arene Ruthenium(II) Complexes as Low-Toxicity Inhibitor against the Proliferation, Migration, and Invasion of MDA-MB-231 Cells through Binding and Stabilizing c-myc G-Quadruplex DNA

2016 / Organometallics

Arene Ru(II) complexes have long been extensively studied as potential inhibitors against the proliferation of tumor cells, but their behavior …

Leah Pandiscia, PhD

Binding interaction, conformational change, and molecular docking study of N-(pyridin-2-ylmethylene)aniline derivatives and carbazole Ru(II) complexes with human serum albumins

2016 / Polyhedron

New [RuCl2(1,5cod)(L1)] (1), [RuCl2(1,5cod)(L2)] (2), [RuCl2(1,5cod)(L3)] (3), [RuCl2(1,5cod)(L4)] (4), [RuCl2(1,5cod)(L5)] (5) (L = (p-R-N-(pyridin-2-ylmethylene)aniline), R = H (L1), Cl (L2), OCH3 (L3), CH3 (L4), L5 = (9-ethyl-N-(pyridin-2-ylmethylene)9H-carbazole-3-amine and 1,5cod = η4-cyclooctadiene) …

Leah Pandiscia, PhD

Synthesis, Characterization, and Application of Platinum(II) Complexes Incorporating Racemic and Optically Active 4-Chloro-5-Methyl-1-Phenyl-1,2,3,6-Tetrahydrophosphinine Ligand

2016 / Heteroatom Chemistry

An efficient resolution method was elaborated for the preparation of (+)-4-chloro-5-methyl-1-phenyl-1,2,3,6-tetrahydrophosphinine oxide using the acidic Ca2+ salt of (–)-O,O-di-p-toluoyl-(2R,3R)-tartaric acid. Crystal …

Leah Pandiscia, PhD

Structure and Dynamics of Antifreeze Protein – Model Membrane Interactions: A Combined Spectroscopic and Molecular Dynamics Study

2016 / The Journal of Physical Chemistry B

Antifreeze proteins (AFPs) are the key biomolecules that enable species to survive under subzero temperature conditions. The physiologically relevant activities …

Leah Pandiscia, PhD

Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs

2016 / Nanoscale

DNA-based molecular logic computation has drawn extensive attention in bioanalysis, intelligent diagnostics of diseases and other nanotechnology areas. Herein, taking …

Leah Pandiscia, PhD

Investigation on the Interaction of Hydroxyethyl Starch 130/0.4 (Voluven) and Serum Albumin for Pharmacokinetic and Toxicological Implications

2015 / Journal of Biochemical and Molecular Toxicology

The interaction of hydroxyethyl starch 130/0.4 (Voluven) with human serum albumin (HSA) has been investigated by fluorescence (steady state and …

Leah Pandiscia, PhD

Layer-by-layer films containing peptides of the Cry1Ab16 toxin from Bacillus thuringiensis for potential biotechnological applications

2016 / Materials Science and Engineering: C

Cry1Ab16 is a toxin of crystalline insecticidal proteins that has been widely used in genetically modified organisms (GMOs) to gain …

Leah Pandiscia, PhD

Copper(II), palladium(II) and platinum(II) complexes with 2,2-thiophen-yl-imidazole: Synthesis, spectroscopic characterization, X-ray crystallographic studies and interactions with calf-thymus DNA

2016 / Inorganica Chimica Acta

New Cu(II), Pd(II) and Pt(II) complexes with 2,2-thiophen-yl-imidazole (Thim) were synthesized. Elemental and MS analyses indicate the [MCl2(Thim)2] composition. The …

Leah Pandiscia, PhD