Protein conformation in pure and hydrated deep eutectic solvents

July 28, 2017

Title

Protein conformation in pure and hydrated deep eutectic solvents

Author

A. Sanchez-Fernandez, K. J. Edler, T. Arnold, D. Alba Venero, A. J. Jackson

Year

2017

Journal

Physical Chemistry Chemical Physics

Abstract

Deep eutectic solvents (DES) have recently been postulated as possible environments where protein structure may be preserved in the absence of water. Here we present our results towards understanding protein conformation in choline chloride-based DES and mixtures with water. Lysozyme and bovine serum albumin have been investigated by means of circular dichroism and small-angle neutron scattering.

Instrument

J-815

Keywords

Circular dichroism, Secondary structure, Tertiary structure, Chemical stability, Thermal stability, Biochemistry