Title
Secondary Structure‐Driven Hydrogelation Using Foldable Telechelic Polymer–Peptide Conjugates
Author
Ronja Otter, Nina Alexandra Henke, Christian Berac, Tobias Bauer, Matthias Barz, Sebastian Seiffert, Pol Besenius
Year
2018
Journal
Macromolecular Rapid Communications
Abstract
The synthesis of ABA and ABA′ triblock polyethylene glycol‐and polysarcosine‐peptide conjugates is reported. The A/A′ peptides are based on phenylalanine(F)‐histidine(H) pentapeptide sequences FHFHF, which promote pH‐switchable β‐sheet self‐assembly into nanorods in water. Only parallel β‐sheet‐driven folding and intermolecular assembly using ABA triblock polymer–peptide conjugates leads to interstrand cross‐linking and hydrogelation, highlighting the impact of supramolecular interactions‐directed structure formation at the nano‐ and mesoscopic level.
Instrument
J-815
Keywords
Circular dichroism, Secondary structure, Chemical stability, Polymers, Protein folding, Biochemistry, Materials