Title
Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del
Author
Meng-Ling Zhao
Year
2021
Journal
Fitoterapia
Abstract
Vernoramyosides A-F (1–6), six new Δ7,9(11) stigmastane-type steroid saponins, along with four known analogues (7–10) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α,β-unsaturated five-membered lactone ring. All isolates were screened for their activities in reversing resistance in MCF/DOX cells.
Instrument
J-1500, P-1020
Keywords
Vernoramyosides, structure